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Matrix effects of the hydroethanolic extract and the butanol fraction of calyces from Physalis peruviana L. on the biopharmaceutics classification of rutin

dc.contributor.authorDomınguez More, Gina Paola
dc.contributor.otherFeltrin, Clarissa
dc.contributor.otherFreire Brambila, Paula
dc.contributor.otherCardona, Maria Isabel
dc.contributor.otherEcheverry, Sandra Milena
dc.contributor.otherOliveira Simoes, Claudia Maria
dc.contributor.otherAragon, Diana Marcela
dc.date.accessioned2022-11-15T21:19:10Z
dc.date.available2022-11-15T21:19:10Z
dc.date.issued2020-02-09
dc.date.submitted2019-08-07
dc.identifier.urihttps://hdl.handle.net/20.500.12834/974
dc.description.abstractObjectives The Biopharmaceutics Classification System (BCS) categorizes active pharmaceutical ingredients according to their solubility and permeability properties, which are susceptible to matrix or formulation effects. The aim of this research was to evaluate the matrix effects of a hydroethanolic extract of calyces from Physalis peruviana L. (HEE) and its butanol fraction (BF), on the biopharmaceutics classification of their major compound, quercetin-3-O-rutinoside (rutin, RU). Methods Rutin was quantified by HPLC-UV, and Caco-2 cell monolayer transport studies were performed to obtain the apparent permeability values (Papp). Aqueous solubility was determined at pH 6.8 and 7.4. Key findings The Papp values followed this order: BF > HEE > RU (1.77 0.02 > 1.53 0.07 > 0.90 0.03 9 10 5 cm/s). The lowest solubility values followed this order: HEE > RU > BF (2.988 0.07 > 0.205 0.002 > 0.189 0.005 mg/ml). Conclusions According to these results, rutin could be classified as BCS classes III (high solubility/low permeability) and IV (low solubility/low permeability), depending on the plant matrix. Further work needs to be done in order to establish how apply the BCS for research and development of new botanical drugs or for bioequivalence purposes.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceBlackwell Publishing Ltdspa
dc.titleMatrix effects of the hydroethanolic extract and the butanol fraction of calyces from Physalis peruviana L. on the biopharmaceutics classification of rutinspa
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datacite.rightshttp://purl.org/coar/access_right/c_abf2spa
oaire.resourcetypehttp://purl.org/coar/resource_type/c_6501spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.audiencePúblico generalspa
dc.identifier.doi10.1111/jphp.13248
dc.identifier.instnameUniversidad del Atlánticospa
dc.identifier.reponameRepositorio Universidad del Atlánticospa
dc.rights.ccAttribution-NonCommercial 4.0 International*
dc.subject.keywordsBiopharmaceutics Classification System; Caco-2 cells; permeability; Physalis peruviana; rutin; solubilityspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículospa
dc.publisher.placeBarranquillaspa
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessspa
dc.publisher.disciplineFarmaciaspa
dc.publisher.sedeSede Nortespa


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