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In vitro anti-leishmanial effect of metallic meso-substituted porphyrin derivatives against Leishmania braziliensis and Leishmania panamensis promastigotes properties
| dc.contributor.author | Espitia-Almeida, Fabian | |
| dc.contributor.other | Díaz-Uribe, Carlos | |
| dc.contributor.other | Vallejo, William | |
| dc.contributor.other | Gómez-Camargo, Doris | |
| dc.contributor.other | Romero Bohórquez, Arnold R. | |
| dc.date.accessioned | 2022-11-15T21:16:14Z | |
| dc.date.available | 2022-11-15T21:16:14Z | |
| dc.date.issued | 2020-04-19 | |
| dc.date.submitted | 2020-03-23 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12834/965 | |
| dc.description.abstract | In this study, a family of porphyrins based on 5,10,15,20-Tetrakis(4-ethylphenyl)porphyrin (1, Ph) and six metallo-derivatives (Zn2+(2, Ph-Zn), Sn4+(3, Ph-Sn), Mn2+ (4, Ph-Mn), Ni2+ (5, Ph-Ni), Al3+ (6, Ph-Al), and V3+ (7, Ph-V)) were tested as photosensitizers for photodynamic therapy against Leishmania braziliensis and panamensis. The singlet oxygen quantum yield value (FD) for (1–7) was measured using 1,3-diphenylisobenzofuran (DPBF) as a singlet oxygen trapping agent and 5,10,15,20-(tetraphenyl)-porphyrin (H2TPP) as a reference standard; besides, parasite viability was estimated by the MTT assay. After metal insertion into the porphyrin core, the FD increased from 0.76–0.90 and cell viability changed considerably. The FD and metal type changed the cytotoxic activity. Finally, (2) showed both the highest FD (0.90) and the best photodynamic activity against the parasites studied (IC50 of 1.2 M). | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | eng | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.source | MDPI AG | spa |
| dc.title | In vitro anti-leishmanial effect of metallic meso-substituted porphyrin derivatives against Leishmania braziliensis and Leishmania panamensis promastigotes properties | spa |
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| datacite.rights | http://purl.org/coar/access_right/c_abf2 | spa |
| oaire.resourcetype | http://purl.org/coar/resource_type/c_6501 | spa |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
| dc.audience | Público general | spa |
| dc.identifier.doi | doi:10.3390/molecules25081887 | |
| dc.identifier.instname | Universidad del Atlántico | spa |
| dc.identifier.reponame | Repositorio Universidad del Atlántico | spa |
| dc.rights.cc | Attribution-NonCommercial 4.0 International | * |
| dc.subject.keywords | porphyrin; metalloporphyrins; photodynamic therapy; Leishmania braziliensis; Leishmania panamensis; singlet oxygen | spa |
| dc.type.driver | info:eu-repo/semantics/article | spa |
| dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | spa |
| dc.type.spa | Artículo | spa |
| dc.publisher.place | Barranquilla | spa |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | spa |
| dc.publisher.sede | Sede Norte | spa |
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