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ADHD Endophenotypes in Caribbean Families

dc.contributor.authorCervantes-Henríquez, M. L.
dc.contributor.otherAcosta-López, J. E.
dc.contributor.otherMartínez-Banfi, M. L.
dc.contributor.otherVélez, J. I.
dc.contributor.otherMejía-Segura, , E.
dc.contributor.otherLozano-Gutiérrez, S. G.
dc.contributor.otherSánchez-Rojas1, M.
dc.contributor.otherZurbarán, M. A.
dc.contributor.otherZurek, E. E.
dc.contributor.otherArcos-Burgos, M.
dc.contributor.otherPineda, D. A.
dc.contributor.otherPuentes-Rozo, P. J.
dc.date.accessioned2022-11-15T21:03:45Z
dc.date.available2022-11-15T21:03:45Z
dc.date.issued2018-03-28
dc.date.submitted2018-03-28
dc.identifier.urihttps://hdl.handle.net/20.500.12834/933
dc.description.abstractObjective: The aim of this study is to contrast the genetics of neuropsychological tasks in individuals from nuclear families clustering ADHD in a Caribbean community. Method: We recruited and clinically characterized 408 individuals using an extensive battery of neuropsychological tasks. The genetic variance underpinning these tasks was estimated by heritability. A predictive framework for ADHD diagnosis was derived using these tasks. Results: We found that individuals with ADHD differed from controls in tasks of mental control, visuospatial ability, visuoverbal memory, phonological and verbal fluency, verbal and semantic fluency, cognitive flexibility, and cognitive ability. Among them, tasks of mental control, visuoverbal memory, phonological fluency, semantic verbal fluency, and intelligence had a significant heritability. A predictive model of ADHD diagnosis using these endophenotypes yields remarkable classification rate, sensitivity, specificity, and precision values (above 80%). Conclusion: We have dissected new cognitive endophenotypes in ADHD that can be suitable to assess the neurobiological and genetic basis of ADHD. (J. of Att. Dis. XXXX; XX(X) XX-XXspa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceJournal of Attention Disordersspa
dc.titleADHD Endophenotypes in Caribbean Familiesspa
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dcterms.bibliographicCitationWechsler, D. (2003). Escala Wechsler de Inteligencia para adultos-III[[Wechsler Intelligence Test for Adults-III]. México: Manual Moderno.spa
dcterms.bibliographicCitationWechsler, D. (2004). Escala de memoria de Wechsler-III: Ediciones TEA [Wechsler Memory Scale-III]. Madrid, Spain. Estonia: TEAspa
dcterms.bibliographicCitationWillcutt, E. G., Betjemann, R. S., McGrath, L. M., Chhabildas, N. A., Olson, R. K., DeFries, J. C., & Pennington, B. F. (2010). Etiology and neuropsychology of comorbidity between RD and ADHD: The case for multiple-deficit models. Cortex, 46, 1345-1361. doi:10.1016/j.cortex.2010.06.009spa
dcterms.bibliographicCitationWillcutt, E. G., Doyle, A. E., Nigg, J. T., Faraone, S. V., & Pennington, B. F. (2005). Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review. Biological Psychiatry, 57, 1336-1346. doi:10.1016/j.biopsych.2005.02.006spa
dcterms.bibliographicCitationWillcutt, E. G., Pennington, B. F., Duncan, L., Smith, S. D., Keenan, J. M., Wadsworth, S., . . . Olson, R. K. (2010). Understanding the complex etiologies of developmental disorders: Behavioral and molecular genetic approaches. Journal of Developmental and Behavioral Pediatrics, 31, 533-544. doi:10.1097/DBP.0b013e3181ef42a1spa
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dc.audiencePúblico generalspa
dc.identifier.doi10.1177/1087054718763741
dc.identifier.instnameUniversidad del Atlánticospa
dc.identifier.reponameRepositorio Universidad del Atlánticospa
dc.rights.ccAttribution-NonCommercial 4.0 International*
dc.subject.keywordsADHD, endophenotypes, attention, memory, genetics, heritabilityspa
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dc.type.spaArtículospa
dc.publisher.placeBarranquillaspa
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessspa
dc.publisher.sedeSede Nortespa


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