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dc.contributor.authorGrande Tovar, Carlos David
dc.contributor.otherCastro, Jorge Iván
dc.contributor.otherValencia, Carlos Humberto
dc.contributor.otherNavia Porras, Diana Paola
dc.contributor.otherMina Hernandez, José Herminsul
dc.contributor.otherValencia, Mayra Eliana
dc.contributor.otherVelásquez, José Daniel
dc.contributor.otherChaur, Manuel N.
dc.date.accessioned2023-01-17T16:17:06Z
dc.date.available2023-01-17T16:17:06Z
dc.date.issued2019-11-01
dc.date.submitted2019-10-08
dc.identifier.urihttps://hdl.handle.net/20.500.12834/1164
dc.description.abstractRecently, tissue engineering became a very important medical alternative in patients who need to regenerate damaged or lost tissues through the use of scaffolds that support cell adhesion and proliferation. Carbon nanomaterials (carbon nanotubes, fullerenes, multi-wall fullerenes, and graphene) became a very important alternative to reinforce the mechanical, thermal, and antimicrobial properties of several biopolymers. In this work, five different formulations of chitosan/poly(vinyl alcohol)/oxidized carbon nano-onions (CS/PVA/ox-CNO) were used to prepare biodegradable scaffolds with potential biomedical applications. Film characterization consisted of Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), tension strength, Young’s modulus, X-ray diffraction spectroscopy (XRD), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS). The degradation in a simulated body fluid (FBS) demonstrated that all the formulations lost between 75% and 80% of their weight after 15 days of treatment, but the degradation decreased with the ox-CNO content. In vivo tests after 90 days of subdermal implantation of the nanocomposite films in Wistar rats’ tissue demonstrated good biocompatibility without allergenic reactions or pus formation. There was a good correlation between FBS hydrolytic degradation and degradation in vivo for all the samples, since the ox-CNO content increased the stability of the material. All these results indicate the potential of the CS/PVA/ox-CNO nanocomposite films in tissue engineering, especially for long-term applications.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titlePreparation of chitosan/poly(Vinyl alcohol) nanocomposite films incorporated with oxidized carbon nano-onions (multi-layer fullerenes) for tissue-engineering applicationsspa
dcterms.bibliographicCitation1. Kelleher, C.M.; Vacanti, J.P. Engineering extracellular matrix through nanotechnology. J. R. Soc. Interface 2010, 7, S717–S729spa
dcterms.bibliographicCitation2. Guo, B.; Sun, Y.; Finne-Wistrand, A.; Mustafa, K.; Albertsson, A.-C. Electroactive porous tubular scaffolds with degradability and non-cytotoxicity for neural tissue regeneration. Acta Biomater. 2012, 8, 144–153.spa
dcterms.bibliographicCitation3. Agarwal, S.; Wendorff, J.H.; Greiner, A. Use of electrospinning technique for biomedical applications. Polymer 2008, 49, 5603–5621spa
dcterms.bibliographicCitation4. Gomes, M.E.; Azevedo, H.S.; Moreira, A.R.; Ellä, V.; Kellomäki, M.; Reis, R.L. Starch–poly (ε-caprolactone) and starch–poly (lactic acid) fibre-mesh scaffolds for bone tissue engineering applications: Structure, mechanical properties and degradation behaviour. J. Tissue Eng. Regen. Med. 2008, 2, 243–252spa
dcterms.bibliographicCitation5. Hollister, S.J. Porous scaffold design for tissue engineering. Nat. Mater. 2005, 4, 518–524spa
dcterms.bibliographicCitation6. Antunes, J.C.; Oliveira, J.M.; Reis, R.L.; Soria, J.M.; Gómez-Ribelles, J.L.; Mano, J.F. Novel poly (L-lactic acid)/hyaluronic acid macroporous hybrid scaffolds: Characterization and assessment of cytotoxicity. J. Biomed. Mater. Res. Part A 2010, 94, 856–869spa
dcterms.bibliographicCitation7. Stratton, S.; Shelke, N.B.; Hoshino, K.; Rudraiah, S.; Kumbar, S.G. Bioactive polymeric scaffolds for tissue engineering. Bioact. Mater. 2016, 1, 93–108spa
dcterms.bibliographicCitation8. Dhandayuthapani, B.; Yoshida, Y.; Maekawa, T.; Kumar, D.S. Polymeric scaffolds in tissue engineering application: A review. Int. J. Polym. Sci. 2011, 2011spa
dcterms.bibliographicCitation9. Narayanan, G.; Gupta, B.S.; Tonelli, A.E. Poly(ε-caprolactone) Nanowebs Functionalized with α- and γ-Cyclodextrins. Biomacromolecules 2014, 15, 4122–4133.spa
dcterms.bibliographicCitation10. Shelke, N.B.; Anderson, M.; Idrees, S.; Nip, M.J.; Donde, S.; Yu, X. Handbook of Polyester Drug Delivery Systems; Pan Stanford Publishing: Singapore, 2016; pp. 595–649.spa
dcterms.bibliographicCitation11. Müller, F.A.; Müller, L.; Hofmann, I.; Greil, P.; Wenzel, M.M.; Staudenmaier, R. Cellulose-based scaffold materials for cartilage tissue engineering. Biomaterials 2006, 27, 3955–3963.spa
dcterms.bibliographicCitation12. Venkatesan, J.; Bhatnagar, I.; Manivasagan, P.; Kang, K.-H.; Kim, S.-K. Alginate composites for bone tissue engineering: A review. Int. J. Biol. Macromol. 2015, 72, 269–281spa
dcterms.bibliographicCitation13. Saravanan, S.; Leena, R.S.; Selvamurugan, N. Chitosan based biocomposite scaffolds for bone tissue engineering. Int. J. Biol. Macromol. 2016, 93, 1354–1365spa
dcterms.bibliographicCitation14. Niranjan, R.; Koushik, C.; Saravanan, S.; Moorthi, A.; Vairamani, M.; Selvamurugan, N. A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering. Int. J. Biol. Macromol. 2013, 54, 24–29.spa
dcterms.bibliographicCitation15. Shui, W.; Zhang, W.; Yin, L.; Nan, G.; Liao, Z.; Zhang, H.; Wang, N.; Wu, N.; Chen, X.; Wen, S. Characterization of scaffold carriers for BMP9-transduced osteoblastic progenitor cells in bone regeneration. J. Biomed. Mater. Res. Part A 2014, 102, 3429–3438.spa
dcterms.bibliographicCitation16. McFadden, T.M.; Duffy, G.P.; Allen, A.B.; Stevens, H.Y.; Schwarzmaier, S.M.; Plesnila, N.; Murphy, J.M.; Barry, F.P.; Guldberg, R.E.; O’brien, F.J. The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen–glycosaminoglycan scaffold in vivo. Acta Biomater. 2013, 9, 9303–9316spa
dcterms.bibliographicCitation17. Lin, C.-Y.; Chang, Y.-H.; Li, K.-C.; Lu, C.-H.; Sung, L.-Y.; Yeh, C.-L.; Lin, K.-J.; Huang, S.-F.; Yen, T.-C.; Hu, Y.-C. The use of ASCs engineered to express BMP2 or TGF-β3 within scaffold constructs to promote calvarial bone repair. Biomaterials 2013, 34, 9401–9412.spa
dcterms.bibliographicCitation18. Sun, Y.; Jiang, Y.; Liu, Q.; Gao, T.; Feng, J.Q.; Dechow, P.; D’Souza, R.N.; Qin, C.; Liu, X. Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration. Tissue Eng. Part A 2013, 19, 1754–1763spa
dcterms.bibliographicCitation19. Saravanan, S.; Nethala, S.; Pattnaik, S.; Tripathi, A.; Moorthi, A.; Selvamurugan, N. Preparation, characterization and antimicrobial activity of a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver for bone tissue engineering. Int. J. Biol. Macromol. 2011, 49, 188–193spa
dcterms.bibliographicCitation20. Jae-Young, J.E.; Se-Kwon, K.I.M. Chitosan as potential marine nutraceutical. In Advances in Food and Nutrition Research; Academic Press: Waltham, MA, USA, 2012; pp. 121–135.spa
dcterms.bibliographicCitation21. El Knidri, H.; Belaabed, R.; Addaou, A.; Laajeb, A.; Lahsini, A. Extraction, chemical modification and characterization of chitin and chitosan: A review. Int. J. Biol. Macromol. 2018spa
dcterms.bibliographicCitation22. Sivashankari, P.R.; Prabaharan, M. Prospects of chitosan-based scaffolds for growth factor release in tissue engineering. Int. J. Biol. Macromol. 2016, 93, 1382–1389.spa
dcterms.bibliographicCitation23. Soundarya, S.P.; Menon, A.H.; Chandran, S.V.; Selvamurugan, N. Bone tissue engineering: Scaffold preparation using chitosan and other biomaterials with different design and fabrication techniques. Int. J. Biol. Macromol. 2018, 119, 1228–1239spa
dcterms.bibliographicCitation24. Dhivya, S.; Keshav Narayan, A.; Logith Kumar, R.; Viji Chandran, S.; Vairamani, M.; Selvamurugan, N. Proliferation and differentiation of mesenchymal stem cells on scaffolds containing chitosan, calcium polyphosphate and pigeonite for bone tissue engineering. Cell Prolif. 2018, 51, e12408.spa
dcterms.bibliographicCitation25. Shamekhi, M.A.; Mirzadeh, H.; Mahdavi, H.; Rabiee, A.; Mohebbi-Kalhori, D.; Eslaminejad, M.B. Graphene oxide containing chitosan scaffolds for cartilage tissue engineering. Int. J. Biol. Macromol. 2019, 127, 396–405.spa
dcterms.bibliographicCitation26. Kashi, M.; Baghbani, F.; Moztarzadeh, F.; Mobasheri, H.; Kowsari, E. Green synthesis of degradable conductive thermosensitive oligopyrrole/chitosan hydrogel intended for cartilage tissue engineering. Int. J. Biol. Macromol. 2018, 107, 1567–1575.spa
dcterms.bibliographicCitation27. Ahmad, M.; Manzoor, K.; Ahmad, S.; Akram, N.; Ikram, S. Chitosan-based nanocomposites for cardiac, liver, and wound healing applications. In Applications of Nanocomposite Materials in Orthopedics; Elsevier: Amsterdam, The Netherlands, 2019; pp. 253–262.spa
dcterms.bibliographicCitation28. Wu, G.; Deng, X.; Song, J.; Chen, F. Enhanced biological properties of biomimetic apatite fabricated polycaprolactone/chitosan nanofibrous bio-composite for tendon and ligament regeneration. J. Photochem. Photobiol. B Biol. 2018, 178, 27–32.spa
dcterms.bibliographicCitation29. Chen, E.; Yang, L.; Ye, C.; Zhang, W.; Ran, J.; Xue, D.; Wang, Z.; Pan, Z.; Hu, Q. An asymmetric chitosan scaffold for tendon tissue engineering: In vitro and in vivo evaluation with rat tendon stem/progenitor cells. Acta Biomater. 2018, 73, 377–387spa
dcterms.bibliographicCitation30. Qasim, S.; Zafar, M.; Najeeb, S.; Khurshid, Z.; Shah, A.; Husain, S.; Rehman, I. Electrospinning of chitosan-based solutions for tissue engineering and regenerative medicine. Int. J. Mol. Sci. 2018, 19, 407.spa
dcterms.bibliographicCitation31. González-Quevedo, D.; Martínez-Medina, I.; Campos, A.; Campos, F.; Carriel, V. Tissue engineering strategies for the treatment of tendon injuries: A systematic review and meta-analysis of animal models. Bone Joint Res. 2018, 7, 318–324spa
dcterms.bibliographicCitation32. Ueno, H.; Mori, T.; Fujinaga, T. Topical formulations and wound healing applications of chitosan. Adv. Drug Deliv. Rev. 2001, 52, 105–115spa
dcterms.bibliographicCitation33. Ratner, B.D.; Hoffman, A.S.; Schoen, F.J.; Lemons, J.E. Biomaterials Science: An Introduction to Materials in Medicine; Elsevier: Amsterdam, The Netherlands, 2004; ISBN 008047036X.spa
dcterms.bibliographicCitation34. Thakur, V.K.; Voicu, S.I. Recent advances in cellulose and chitosan based membranes for water purification: A concise review. Carbohydr. Polym. 2016, 146, 148–165.spa
dcterms.bibliographicCitation35. He, Y.; Miao, J.; Chen, S.; Zhang, R.; Zhang, L.; Tang, H.; Yang, H. Preparation and characterization of a novel positively charged composite hollow fiber nanofiltration membrane based on chitosan lactate. RSC Adv. 2019, 9, 4361–4369spa
dcterms.bibliographicCitation36. Medina, V.F.; Griggs, C.S.; Mattei-Sosa, J.; Petery, B.; Gurtowski, L. Advanced filtration membranes using chitosan and graphene oxide. U.S. Patent Application No 15/671,043, 7 Feburary 2019.spa
dcterms.bibliographicCitation37. Sun, T.; Guo, X.; Zhong, R.; Ma, L.; Li, H.; Gu, Z.; Guan, J.; Tan, H.; You, C.; Tian, M. Interactions of oligochitosan with blood components. Int. J. Biol. Macromol. 2019, 124, 304–313spa
dcterms.bibliographicCitation38. Heise, K.; Hobisch, M.; Sacarescu, L.; Maver, U.; Hobisch, J.; Reichelt, T.; Sega, M.; Fischer, S.; Spirk, S. Low-molecular-weight sulfonated chitosan as template for anticoagulant nanoparticles. Int. J. Nanomedicine 2018, 13, 4881spa
dcterms.bibliographicCitation39. Guo, X.; Sun, T.; Zhong, R.; Ma, L.; You, C.; Tian, M.; Li, H.; Wang, C. Effects of chitosan oligosaccharides on human blood components. Front. Pharmacol. 2018, 9, 1412spa
dcterms.bibliographicCitation40. Dimassi, S.; Tabary, N.; Chai, F.; Blanchemain, N.; Martel, B. Sulfonated and sulfated chitosan derivatives for biomedical applications: A review. Carbohydr. Polym. 2018.spa
dcterms.bibliographicCitation41. Mehta, P.; Al-Kinani, A.A.; Arshad, M.S.; Singh, N.; van der Merwe, S.M.; Chang, M.-W.; Alany, R.G.; Ahmad, Z. Engineering and development of chitosan-based Nanocoatings for Ocular Contact Lenses. J. Pharm. Sci. 2019, 108, 1540–1551spa
dcterms.bibliographicCitation42. Ali, A.; Ahmed, S. A review on chitosan and its nanocomposites in drug delivery. Int. J. Biol. Macromol. 2018, 109, 273–286spa
dcterms.bibliographicCitation43. Ahsan, S.M.; Thomas, M.; Reddy, K.K.; Sooraparaju, S.G.; Asthana, A.; Bhatnagar, I. Chitosan as biomaterial in drug delivery and tissue engineering. Int. J. Biol. Macromol. 2018, 110, 97–109spa
dcterms.bibliographicCitation44. Gomillion, C.T. Assessing the Potential of Chitosan/Polylactide Nanoparticles for Delivery of Therapeutics for Triple-Negative Breast Cancer Treatment. Regen. Eng. Transl. Med. 2019, 5, 61–73.spa
dcterms.bibliographicCitation45. Raval, R.; Rangnekar, R.H.; Raval, K. Optimization of chitosan nanoparticles synthesis and its applications in fatty acid absorption. In Materials, Energy and Environment Engineering; Springer: Berlin/Heidelberg, Germany, 2017; pp. 253–256.spa
dcterms.bibliographicCitation46. Berkland, C.; Qian, J.; Sullivan, B.P. Micelle sequestering polymers. U.S. Patent No 9,675,636, 13 June 2017spa
dcterms.bibliographicCitation47. Hamedi, H.; Moradi, S.; Hudson, S.M.; Tonelli, A.E. Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review. Carbohydr. Polym. 2018, 199, 445–460.spa
dcterms.bibliographicCitation48. Mohebbi, S.; Nezhad, M.N.; Zarrintaj, P.; Jafari, S.H.; Gholizadeh, S.S.; Saeb, M.R.; Mozafari, M. Chitosan in biomedical engineering: A critical review. Curr. Stem Cell Res. Ther. 2019, 14, 93–116spa
dcterms.bibliographicCitation49. Cazón, P.; Vázquez, M. Applications of Chitosan as Food Packaging Materials. In Sustainable Agriculture Reviews 36; Springer: Berlin/Heidelberg, Germany, 2019; pp. 81–123.spa
dcterms.bibliographicCitation50. Wang, H.; Qian, J.; Ding, F. Emerging chitosan-based films for food packaging applications. J. Agric. Food Chem. 2018, 66, 395–413spa
dcterms.bibliographicCitation51. Seol, Y.-J.; Lee, J.-Y.; Park, Y.-J.; Lee, Y.-M.; Rhyu, I.-C.; Lee, S.-J.; Han, S.-B.; Chung, C.-P. Chitosan sponges as tissue engineering scaffolds for bone formation. Biotechnol. Lett. 2004, 26, 1037–1041.spa
dcterms.bibliographicCitation52. ¸Senel, S.; McClure, S.J. Potential applications of chitosan in veterinary medicine. Adv. Drug Deliv. Rev. 2004, 56, 1467–1480.spa
dcterms.bibliographicCitation53. Di Martino, A.; Sittinger, M.; Risbud, M. V Chitosan: A versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 2005, 26, 5983–5990.spa
dcterms.bibliographicCitation54. Aranaz, I.; Mengíbar, M.; Harris, R.; Paños, I.; Miralles, B.; Acosta, N.; Galed, G.; Heras, Á. Functional characterization of chitin and chitosan. Curr. Chem. Biol. 2009, 3, 203–230spa
dcterms.bibliographicCitation55. Pattnaik, S.; Nethala, S.; Tripathi, A.; Saravanan, S.; Moorthi, A.; Selvamurugan, N. Chitosan scaffolds containing silicon dioxide and zirconia nano particles for bone tissue engineering. Int. J. Biol. Macromol. 2011, 49, 1167–1172spa
dcterms.bibliographicCitation56. Sowjanya, J.A.; Singh, J.; Mohita, T.; Sarvanan, S.; Moorthi, A.; Srinivasan, N.; Selvamurugan, N. Biocomposite scaffolds containing chitosan/alginate/nano-silica for bone tissue engineering. Colloids Surfaces B Biointerfaces 2013, 109, 294–300.spa
dcterms.bibliographicCitation57. Moorthi, A.; Parihar, P.R.; Saravanan, S.; Vairamani, M.; Selvamurugan, N. Effects of silica and calcium levels in nanobioglass ceramic particles on osteoblast proliferation. Mater. Sci. Eng. C 2014, 43, 458–464spa
dcterms.bibliographicCitation58. Ajita, J.; Saravanan, S.; Selvamurugan, N. Effect of size of bioactive glass nanoparticles on mesenchymal stem cell proliferation for dental and orthopedic applications. Mater. Sci. Eng. C 2015, 53, 142–149spa
dcterms.bibliographicCitation59. Sainitya, R.; Sriram, M.; Kalyanaraman, V.; Dhivya, S.; Saravanan, S.; Vairamani, M.; Sastry, T.P.; Selvamurugan, N. Scaffolds containing chitosan/carboxymethyl cellulose/mesoporous wollastonite for bone tissue engineering. Int. J. Biol. Macromol. 2015, 80, 481–488spa
dcterms.bibliographicCitation60. Moorthi, A.; Saravanan, S.; Srinivasan, N.; Partridge, N.C.; Zhu, J.; Qin, L.; Selvamurugan, N. Synthesis, characterization and biological action of nano-bioglass ceramic particles for bone formation. J. Biomater. Tissue Eng. 2012, 2, 197–205spa
dcterms.bibliographicCitation61. Saravanan, S.; Vimalraj, S.; Vairamani, M.; Selvamurugan, N. Role of mesoporous wollastonite (calcium silicate) in mesenchymal stem cell proliferation and osteoblast differentiation: A cellular and molecular study. J. Biomed. Nanotechnol. 2015, 11, 1124–1138.spa
dcterms.bibliographicCitation62. Amidi, M.; Mastrobattista, E.; Jiskoot, W.; Hennink, W.E. Chitosan-based delivery systems for protein therapeutics and antigens. Adv. Drug Deliv. Rev. 2010, 62, 59–82spa
dcterms.bibliographicCitation63. HPS, A.K.; Saurabh, C.K.; Adnan, A.S.; Fazita, M.R.N.; Syakir, M.I.; Davoudpour, Y.; Rafatullah, M.; Abdullah, C.K.; Haafiz, M.K.M.; Dungani, R. A review on chitosan-cellulose blends and nanocellulose reinforced chitosan biocomposites: Properties and their applications. Carbohydr. Polym. 2016, 150, 216–226.spa
dcterms.bibliographicCitation64. Koosha, M.; Mirzadeh, H.; Shokrgozar, M.A.; Farokhi, M. Nanoclay-reinforced electrospun chitosan/PVA nanocomposite nanofibers for biomedical applications. RSC Adv. 2015, 5, 10479–10487spa
dcterms.bibliographicCitation65. Fan, J.; Grande, C.D.; Rodrigues, D.F. Biodegradation of graphene oxide-polymer nanocomposite films in wastewater. Environ. Sci. Nano 2017, 4, 1808–1816spa
dcterms.bibliographicCitation66. Grande, C.D.; Mangadlao, J.; Fan, J.; De Leon, A.; Delgado-Ospina, J.; Rojas, J.G.; Rodrigues, D.F.; Advincula, R. Chitosan Cross-Linked Graphene Oxide Nanocomposite Films with Antimicrobial Activity for Application in Food Industry. Macromol. Symp. 2017, 374, 1600114-n/aspa
dcterms.bibliographicCitation67. Ruiz, S.; Tamayo, A.J.; Delgado Ospina, J.; Navia Porras, P.D.; Valencia Zapata, E.M.; Mina Hernandez, H.J.; Valencia, H.C.; Zuluaga, F.; Grande Tovar, D.C. Antimicrobial Films Based on Nanocomposites of Chitosan/Poly(vinyl alcohol)/Graphene Oxide for Biomedical Applications. Biomolecules 2019, 9, 109.spa
dcterms.bibliographicCitation68. López Tenorio, D.; Valencia, H.C.; Valencia, C.; Zuluaga, F.; Valencia, E.M.; Mina, H.J.; Grande Tovar, D.C. Evaluation of the Biocompatibility of CS-Graphene Oxide Compounds In Vivo. Int. J. Mol. Sci. 2019, 20, 1572.spa
dcterms.bibliographicCitation69. Valencia, C.; Valencia, C.; Zuluaga, F.; Valencia, M.; Mina, J.; Grande-Tovar, C. Synthesis and Application of Scaffolds of Chitosan-Graphene Oxide by the Freeze-Drying Method for Tissue Regeneration. Molecules 2018, 23, 2651spa
dcterms.bibliographicCitation70. Tamayo Marín, A.J.; Londoño, R.S.; Delgado, J.; Navia Porras, P.D.; Valencia Zapata, E.M.; Mina Hernandez, H.J.; Valencia, H.C.; Grande Tovar, D.C. Biocompatible and Antimicrobial Electrospun Membranes Based on Nanocomposites of Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide. Int. J. Mol. Sci. 2019, 20, 2987spa
dcterms.bibliographicCitation71. Valencia Zapata, E.M.; Mina Hernandez, H.J.; Grande Tovar, D.C.; Valencia Llano, H.C.; Diaz Escobar, A.J.; Vázquez-Lasa, B.; San Román, J.; Rojo, L. Novel Bioactive and Antibacterial Acrylic Bone Cement Nanocomposites Modified with Graphene Oxide and Chitosan. Int. J. Mol. Sci. 2019, 20, 2938spa
dcterms.bibliographicCitation72. Rettenbacher, A.S.; Elliott, B.; Hudson, J.S.; Amirkhanian, A.; Echegoyen, L. Preparation and Functionalization of Multilayer Fullerenes (Carbon Nano-Onions). Chem. – A Eur. J. 2006, 12, 376–387spa
dcterms.bibliographicCitation73. Hirata, A.; Igarashi, M.; Kaito, T. Study on solid lubricant properties of carbon onions produced by heat treatment of diamond clusters or particles. Tribol. Int. 2004, 37, 899–905.spa
dcterms.bibliographicCitation74. Bartelmess, J.; Giordani, S. Carbon nano-onions (multi-layer fullerenes): Chemistry and applications. Beilstein J. Nanotechnol. 2014, 5, 1980–1998spa
dcterms.bibliographicCitation75. Breczko, J.; Winkler, K.; Plonska-Brzezinska, M.E.; Villalta-Cerdas, A.; Echegoyen, L. Electrochemical properties of composites containing small carbon nano-onions and solid polyelectrolytes. J. Mater. Chem. 2010, 20, 7761–7768.spa
dcterms.bibliographicCitation76. Ibáñez-Redín, G.; Furuta, R.H.M.; Wilson, D.; Shimizu, F.M.; Materon, E.M.; Arantes, L.M.R.B.; Melendez, M.E.; Carvalho, A.L.; Reis, R.M.; Chaur, M.N. Screen-printed interdigitated electrodes modified with nanostructured carbon nano-onion films for detecting the cancer biomarker CA19-9. Mater. Sci. Eng. C 2019, 99, 1502–1508spa
dcterms.bibliographicCitation77. Ding, L.; Stilwell, J.; Zhang, T.; Elboudwarej, O.; Jiang, H.; Selegue, J.P.; Cooke, P.A.; Gray, J.W.; Chen, F.F. Molecular Characterization of the Cytotoxic Mechanism of Multiwall Carbon Nanotubes and Nano-Onions on Human Skin Fibroblast. Nano Lett. 2005, 5, 2448–2464.spa
dcterms.bibliographicCitation78. Echegoyen, L.; Ortiz, A.; Chaur, M.N.; Palkar, A.J. Carbon nano onions. Chem. Nanocarbons 2010, 463–483.spa
dcterms.bibliographicCitation79. Sok, V.; Fragoso, A. Preparation and characterization of alkaline phosphatase, horseradish peroxidase, and glucose oxidase conjugates with carboxylated carbon nano-onions. Prep. Biochem. Biotechnol. 2018, 48, 136–143spa
dcterms.bibliographicCitation80. Osswald, S.; Havel, M.; Gogotsi, Y. Monitoring oxidation of multiwalled carbon nanotubes by Raman spectroscopy. J. Raman Spectrosc. 2007, 38, 728–736.spa
dcterms.bibliographicCitation81. Cioffi, C.T.; Palkar, A.; Melin, F.; Kumbhar, A.; Echegoyen, L.; Melle-Franco, M.; Zerbetto, F.; Rahman, G.M.A.; Ehli, C.; Sgobba, V. A carbon nano-onion–ferrocene donor–acceptor system: Synthesis, characterization and properties. Chem. Eur. J. 2009, 15, 4419–4427.spa
dcterms.bibliographicCitation82. Srinivasa, P.C.; Ramesh, M.N.; Kumar, K.R.; Tharanathan, R.N. Properties and sorption studies of chitosan–polyvinyl alcohol blend films. Carbohydr. Polym. 2003, 53, 431–438.spa
dcterms.bibliographicCitation83. Pandele, A.M.; Ionita, M.; Crica, L.; Dinescu, S.; Costache, M.; Iovu, H. Synthesis, characterization, and in vitro studies of graphene oxide/chitosan-polyvinyl alcohol films. Carbohydr. Polym. 2014, 102, 813–820.spa
dcterms.bibliographicCitation84. Zhang, W.; Zhou, C.; Zhou, W.; Lei, A.; Zhang, Q.; Wan, Q.; Zou, B. Fast and considerable adsorption of methylene blue dye onto graphene oxide. Bull. Environ. Contam. Toxicol. 2011, 87, 86.spa
dcterms.bibliographicCitation85. Jia, Y.-T.; Gong, J.; Gu, X.-H.; Kim, H.-Y.; Dong, J.; Shen, X.-Y. Fabrication and characterization of poly (vinyl alcohol)/chitosan blend nanofibers produced by electrospinning method. Carbohydr. Polym. 2007, 67, 403–409.spa
dcterms.bibliographicCitation86. Liu, L.; Li, C.; Bao, C.; Jia, Q.; Xiao, P.; Liu, X.; Zhang, Q. Preparation and characterization of chitosan/graphene oxide composites for the adsorption of Au (III) and Pd (II). Talanta 2012, 93, 350–357.spa
dcterms.bibliographicCitation87. Mallakpour, S.; Zadehnazari, A. A facile, efficient, and rapid covalent functionalization of multi-walled carbon nanotubes with natural amino acids under microwave irradiation. Prog. Org. Coatings 2014, 77, 679–684spa
dcterms.bibliographicCitation88. Mallakpour, S.; Madani, M. A general and efficient route to covalently surface modification of MWCNTs by dopamine and their synergistic reinforcing effects in chitosan films. Prog. Org. Coatings 2015, 85, 131–137spa
dcterms.bibliographicCitation89. Lu, L.; Peng, F.; Jiang, Z.; Wang, J. Poly(vinyl alcohol)/chitosan blend membranes for pervaporation of benzene/cyclohexane mixtures. J. Appl. Polym. Sci. 2006, 101, 167–173.spa
dcterms.bibliographicCitation90. Yang, X.; Tu, Y.; Li, L.; Shang, S.; Tao, X. Well-Dispersed Chitosan/Graphene Oxide Nanocomposites. ACS Appl. Mater. Interfaces 2010, 2, 1707–1713spa
dcterms.bibliographicCitation91. Ionita, M.; Pandele, M.A.; Iovu, H. Sodium alginate/graphene oxide composite films with enhanced thermal and mechanical properties. Carbohydr. Polym. 2013, 94, 339–344.spa
dcterms.bibliographicCitation92. Mallakpour, S.; Ezhieh, A.N. Preparation and characterization of chitosan-poly (vinyl alcohol) nanocomposite films embedded with functionalized multi-walled carbon nanotube. Carbohydr. Polym. 2017, 166, 377–386.spa
dcterms.bibliographicCitation93. Ma, Q.; Liang, T.; Cao, L.; Wang, L. Intelligent poly (vinyl alcohol)-chitosan nanoparticles-mulberry extracts films capable of monitoring pH variations. Int. J. Biol. Macromol. 2018, 108, 576–584spa
dcterms.bibliographicCitation94. Yadav, I.; Nayak, S.K.; Rathnam, V.S.S.; Banerjee, I.; Ray, S.S.; Anis, A.; Pal, K. Reinforcing effect of graphene oxide reinforcement on the properties of poly (vinyl alcohol) and carboxymethyl tamarind gum based phase-separated film. J. Mech. Behav. Biomed. Mater. 2018, 81, 61–71.spa
dcterms.bibliographicCitation95. Zhang, X.; Liu, T.; Sreekumar, T.V.; Kumar, S.; Moore, V.C.; Hauge, R.H.; Smalley, R.E. Poly (vinyl alcohol)/SWNT composite film. Nano Lett. 2003, 3, 1285–1288.spa
dcterms.bibliographicCitation96. FigueiraMaldonado, E. Degradación hidrolítica a diferentes pH de un material compuesto Poli(ácido láctico)/Quitosano; Universidad Simón Bolívar: Mexico City, Mexico, 2008spa
dcterms.bibliographicCitation97. Depan, D.; Shah, J.S.; Misra, R.D.K. Degradation mechanism and increased stability of chitosan-based hybrid scaffolds cross-linked with nanostructured carbon: Process-structure-functional property relationship. Polym. Degrad. Stab. 2013, 98, 2331–2339.spa
dcterms.bibliographicCitation98. Maruyama, M.; Ito, M. In vitro properties of a chitosan-bonded self-hardening paste with hydroxyapatite granules. J. Biomed. Mater. Res. 1996, 32, 527–532.spa
dcterms.bibliographicCitation99. Tomihata, K.; Ikada, Y. In vitro and in vivo degradation of films of chitin and its deacetylated derivatives. Biomaterials 1997, 18, 567–575spa
dcterms.bibliographicCitation100. Pella, M.C.G.; Lima-Tenório, M.K.; Tenorio-Neto, E.T.; Guilherme, M.R.; Muniz, E.C.; Rubira, A.F. Chitosan-based hydrogels: From preparation to biomedical applications. Carbohydr. Polym. 2018, 196, 233–245.spa
dcterms.bibliographicCitation101. Fujita, M.; Ishihara, M.; Simizu, M.; Obara, K.; Ishizuka, T.; Saito, Y.; Yura, H.; Morimoto, Y.; Takase, B.; Matsui, T. Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogel. Biomaterials 2004, 25, 699–706spa
dcterms.bibliographicCitation102. Pawar, V.; Bulbake, U.; Khan, W.; Srivastava, R. Chitosan sponges as a sustained release carrier system for the prophylaxis of orthopedic implant-associated infections. Int. J. Biol. Macromol. 2019, 134, 100–112.spa
dcterms.bibliographicCitation103. Anderson, J.M.; Rodriguez, A.; Chang, D.T. Foreign body reaction to biomaterials. Semin. Immunol. 2008, 20, 86–100spa
dcterms.bibliographicCitation104. Van Putten, S.M.; Ploeger, D.T.A.; Popa, E.R.; Bank, R.A. Macrophage phenotypes in the collagen-induced foreign body reaction in rats. Acta Biomater. 2013, 9, 6502–6510.spa
dcterms.bibliographicCitation105. Klopfleisch, R. Macrophage reaction against biomaterials in the mouse model – Phenotypes, functions and markers. Acta Biomater. 2016, 43, 3–13.spa
dcterms.bibliographicCitation106. Qian, Y.; Li, L.; Song, Y.; Dong, L.; Chen, P.; Li, X.; Cai, K.; Germershaus, O.; Yang, L.; Fan, Y. Surface modification of nanofibrous matrices via layer-by-layer functionalized silk assembly for mitigating the foreign body reaction. Biomaterials 2018, 164, 22–37spa
datacite.rightshttp://purl.org/coar/access_right/c_abf2spa
oaire.resourcetypehttp://purl.org/coar/resource_type/c_6501spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.audiencePúblico generalspa
dc.identifier.doi10.3390/biom9110684
dc.identifier.instnameUniversidad del Atlánticospa
dc.identifier.reponameRepositorio Universidad del Atlánticospa
dc.rights.ccAttribution-NonCommercial 4.0 International*
dc.subject.keywordsbiodegradable filmsspa
dc.subject.keywordschitosanspa
dc.subject.keywordsoxidized carbon nano-onionsspa
dc.subject.keywordspoly(vinyl alcohol)spa
dc.subject.keywordstissue engineeringspa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículospa
dc.publisher.placeBarranquillaspa
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessspa
dc.publisher.sedeSede Nortespa


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