Mostrar el registro sencillo del ítem
Synthesis and fabrication of films including graphene oxide functionalized with chitosan for regenerative medicine applications
| dc.contributor.author | Valencia, Ana María | |
| dc.contributor.other | Valencia, Carlos Humberto | |
| dc.contributor.other | Zuluaga, Fabio | |
| dc.contributor.other | Grande-Tovar, Carlos David | |
| dc.date.accessioned | 2022-12-19T02:43:01Z | |
| dc.date.available | 2022-12-19T02:43:01Z | |
| dc.date.issued | 2021-06-12 | |
| dc.date.submitted | 2020-07-22 | |
| dc.identifier.citation | Valencia AM, Valencia CH, Zuluaga F, Grande-Tovar CD. Synthesis and fabrication of films including graphene oxide functionalized with chitosan for regenerative medicine applications. Heliyon. 2021 May 21;7(5):e07058. doi: 10.1016/j.heliyon.2021.e07058. PMID: 34095569; PMCID: PMC8165423. | spa |
| dc.identifier.uri | https://hdl.handle.net/20.500.12834/1145 | |
| dc.description.abstract | Graphene oxide (GO) has recently gained attention as a scaffold reinforcing agent for tissue engineering. Biomechanical and biological properties through a synergistic effect can be strengthened when combined with other materials such as chitosan (CS). For that reason, chitosan was used for Graphene Oxide (GO) functionalization through an amide group whose formation was evident by bands around 1600 cm 1 in the FTIR analysis. Furthermore, bands located at 1348 cm 1 (D band), 1593 cm 1 (G band), and 2416 cm 1 (2D band) in the RAMAN spectrum, and the displacement of the signal at 87.03 ppm (C5) in solid-state 13C-NMR confirmed the amide formation. Films including the CS-GO compound were prepared and characterized by thermogravimetric analysis (TGA), where CS-GO film presented a lighter mass loss (~10% less loosed) than CS due probably to the covalent functionalization with GO, providing film thermal resistance. The CS-GO films synthesized were implanted in Wistar rats' subdermal tissue as a first approximation to the biological response. In vivo tests showed a low inflammatory response, good cicatrization, and advanced resorption at 60 days of implantation, as indicated by histological images. It was evidenced that the covalent union between CS and GO increased biocompatibility and the degradation/resorption capacity, demonstrating tissue regeneration with typical characteristics and tiny remnants of implanted material surrounded by a type III collagen capsule. These results show the potential application of the new synthesized films, including the CS-GO compound, in tissue engineering. | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.language.iso | eng | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
| dc.source | Heliyon | spa |
| dc.title | Synthesis and fabrication of films including graphene oxide functionalized with chitosan for regenerative medicine applications | spa |
| dc.title.alternative | Synthesis and fabrication of films including graphene oxide functionalized with chitosan for regenerative medicine applications | spa |
| dcterms.bibliographicCitation | M.A. Nguyen, G. Camci-unal Unconventional tissue engineering materials in disguise Trends Biotechnol., 1–13 (2019) | spa |
| dcterms.bibliographicCitation | S. Saber-Samandari, S. Saber-Samandari Biocompatible nanocomposite scaffolds based on copolymer-grafted chitosan for bone tissue engineering with drug delivery capability Mater. Sci. Eng. C, 75 (2017), pp. 721-732 | spa |
| dcterms.bibliographicCitation | A. Abedi, M. Hasanzadeh, L. Tayebi Conductive nanofibrous chitosan/PEDOT:PSS tissue engineering scaffolds Mater. Chem. Phys., 237 (October 2018) (2019), p. 121882 | spa |
| dcterms.bibliographicCitation | L.A. Loureiro dos Santos Natural polymeric biomaterials: processing and properties Ref. Modul. Mater. Sci. Mater. Eng. (2017), pp. 1-6 | spa |
| dcterms.bibliographicCitation | K. Balagangadharan, S. Dhivya, N. Selvamurugan Chitosan based nanofibers in bone tissue engineering Int. J. Biol. Macromol., 104 (2017), pp. 1372-1382 | spa |
| dcterms.bibliographicCitation | A. Muxika, A. Etxabide, J. Uranga, P. Guerrero, K. de la Caba Chitosan as a bioactive polymer: processing, properties and applications Int. J. Biol. Macromol., 105 (2017), pp. 1358-1368 | spa |
| dcterms.bibliographicCitation | S.M. Ahsan, M. Thomas, K.K. Reddy, S.G. Sooraparaju, A. Asthana, I. Bhatnagar Chitosan as biomaterial in drug delivery and tissue engineering Int. J. Biol. Macromol., 110 (2017), pp. 97-109 | spa |
| dcterms.bibliographicCitation | F. Tao, Y. Cheng, X. Shi, H. Zheng, Y. Du, W. Xiang, H. Deng Applications of chitin and chitosan nanofibers in bone regenerative engineering Carbohydr. Polym., 230 (October 2019) (2019), p. 115658 | spa |
| dcterms.bibliographicCitation | .Z. Knaul, S.M. Hudson, K.A.M. Creber Improved mechanical properties of chitosan fibers J. Appl. Polym. Sci., 72 (13) (1999), pp. 1721-1732 | spa |
| dcterms.bibliographicCitation | K. Pieklarz, M. Tylman, Z. Modrzejewska Current progress in biomedical applications of chitosan-carbon nanotube nanocomposites: a review Mini Rev. Med. Chem., 20 (16) (2020), pp. 1619-1632 | spa |
| dcterms.bibliographicCitation | D.C. Grande Tovar, I.J. Castro, H.C. Valencia, P.D. Navia Porras, J. Herminsul Mina Hernandez, E.M. Valencia Zapata, N.M. Chaur Nanocomposite films of chitosan-grafted carbon nano-onions for biomedical applications Molecules (2020) | spa |
| dcterms.bibliographicCitation | C.D. Grande Tovar, J.I. Castro, C.H. Valencia, D.P. Navia Porras, M. Hernandez, J. Herminsul, M.E. Valencia, J.D. Velásquez, M.N. Chaur Preparation of chitosan/poly (vinyl alcohol) nanocomposite films incorporated with oxidized carbon nano-onions (Multi-Layer fullerenes) for tissue-engineering applications Biomolecules, 9 (11) (2019), p. 684 | spa |
| dcterms.bibliographicCitation | B. Sharma, S. Shekhar, P. Jain, R. Sharma, K.K.D. Chauhan Graphene grafted chitosan nanocomposites and their applications Graphene Based Biopolymer Nanocomposites, Springer (2021), pp. 135-147 | spa |
| dcterms.bibliographicCitation | A. Raslan, L.S. Del Burgo, J. Ciriza, J.L. Pedraz Graphene oxide and reduced graphene oxide-based scaffolds in regenerative medicine Int. J. Pharm., 580 (2020), p. 119226 | spa |
| dcterms.bibliographicCitation | D.C. Grande Tovar, I.J. Castro, H.C. Valencia, A.P. Zapata, A.M. Solano, E. Florez López, N.M. Chaur, E.M. Valencia Zapata, H.J. Mina Hernandez Synthesis of chitosan beads incorporating graphene oxide/titanium dioxide nanoparticles for in vivo studies Molecules (2020) | spa |
| dcterms.bibliographicCitation | S.C. Ray Application and Uses of Graphene Oxide and Reduced Graphene Oxide Elsevier Inc. (2015) | spa |
| dcterms.bibliographicCitation | V. Gupta, N. Sharma, U. Singh, M. Arif, A. Singh Higher oxidation level in graphene oxide Optik, 143 (2017), pp. 115-124 | spa |
| dcterms.bibliographicCitation | A.T. Smith, A.M. LaChance, S. Zeng, B. Liu, L. Sun Synthesis, properties, and applications of graphene oxide/reduced graphene oxide and their nanocomposites Nano Mater. Sci., 1 (1) (2019), pp. 31-47 | spa |
| dcterms.bibliographicCitation | B. Yang, P.-B. Wang, N. Mu, K. Ma, S. Wang, C.-Y. Yang, Z.-B. Huang, Y. Lai, H. Feng, G.-F. Yin Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats Neural Regen. Res., 16 (9) (2021), p. 1829 | spa |
| dcterms.bibliographicCitation | C. Xie, X. Lu, L. Han, J. Xu, Z. Wang, L. Jiang, K. Wang, H. Zhang, F. Ren, Y. Tang Biomimetic mineralized hierarchical graphene oxide/chitosan scaffolds with adsorbability for immobilization of nanoparticles for biomedical applications ACS Appl. Mater. Interfaces, 8 (3) (2016), pp. 1707-1717 | spa |
| dcterms.bibliographicCitation | H. Yi, L.Q. Wu, W.E. Bentley, R. Ghodssi, G.W. Rubloff, J.N. Culver, G.F. Payne Biofabrication with chitosan Biomacromolecules, 6 (6) (2005), pp. 2881-2894 | spa |
| dcterms.bibliographicCitation | F. Saeedi, A. Montazeri, Y. Bahari, M. Pishvaei, B. Jannat, M. Rasa, F. Saeedi Fabrication and characterization of chitosan-polyvinyl alcohol-graphene oxide nanocomposite scaffold for wound healing purposes Human, Heal. Halal Metrics, 1 (2) (2021), pp. 47-55 | spa |
| dcterms.bibliographicCitation | N. Amiryaghoubi, M. Fathi, A. Barzegari, J. Barar, H. Omidian, Y. Omidi Recent advances in polymeric scaffolds containing carbon nanotube and graphene oxide for cartilage and bone regeneration Mater. Today Commun. (2021), p. 102097 | spa |
| dcterms.bibliographicCitation | P.P. Zuo, H.F. Feng, Z.Z. Xu, L.F. Zhang, Y.L. Zhang, W. Xia, W.Q. Zhang Fabrication of biocompatible and mechanically reinforced graphene oxide-chitosan nanocomposite films Chem. Cent. J., 7 (1) (2013), pp. 1-11 | spa |
| dcterms.bibliographicCitation | D.L. Tenorio, C.H. Valencia, C. Valencia, F. Zuluaga, M.E. Valencia, J.H. Mina, C.D.G. Tovar Evaluation of the biocompatibility of Cs-graphene oxide compounds in vivo Int. J. Mol. Sci., 20 (7) (2019) | spa |
| dcterms.bibliographicCitation | C. Valencia, C.H. Valencia, F. Zuluaga, M.E. Valencia, J.H. Mina, C.D. Grande-Tovar Synthesis and application of scaffolds of chitosan-graphene oxide by the freeze-drying method for tissue regeneration Molecules, 23 (10) (2018) | spa |
| dcterms.bibliographicCitation | S. Biranje, P. Madiwale, A.R.V. Adicarekar Preparation and characterization of chitosan/pva polymeric film for its potential application as wound dressing Material. Indian J.Sci. Res, 14 (2) (2017), pp. 250-256 | spa |
| dcterms.bibliographicCitation | T. Ramanathan, A.A. Abdala, S. Stankovich, D.A. Dikin, M. Herrera-Alonso, R.D. Piner, D.H. Adamson, H.C. Schniepp, X. Chen, R.S. Ruoff, S.T. Nguyen, I.A. Aksay, R.K. Prud’Homme, L.C. Brinson Functionalized graphene sheets for polymer nanocomposites Nat. Nanotechnol., 3 (6) (2008), pp. 327-331 | spa |
| dcterms.bibliographicCitation | S.H.M. Wong, S.S. Lim, T.J. Tiong, P.L. Show, H.F.M. Zaid, H.-S. Loh Preliminary in vitro evaluation of chitosan–graphene oxide scaffolds on osteoblastic adhesion, proliferation, and early differentiation Int. J. Mol. Sci., 21 (15) (2020), p. 5202 | spa |
| dcterms.bibliographicCitation | L. Carson, C. Kelly-Brown, M. Stewart, A. Oki, G. Regisford, Z. Luo, V.I. Bakhmutov Synthesis and characterization of chitosan-carbon nanotube composites Mater. Lett., 63 (6–7) (2009), pp. 617-620 | spa |
| dcterms.bibliographicCitation | Snežzana Miljanić, Leo Frkanec, Tomislav Biljan, Zlatko Meić Mladen Žini Recent advances in linear and nonlinear Raman spectroscopy I J. Raman Spectrosc., 38 (April) (2007), pp. 1538-1553 | spa |
| dcterms.bibliographicCitation | D.C. Marcano, D.V. Kosynkin, J.M. Berlin, A. Sinitskii, Z. Sun, A. Slesarev, L.B. Alemany, W. Lu, J.M. Tour Improved synthesis of graphene oxide ACS Nano, 4 (8) (2010), pp. 4806-4814 | spa |
| dcterms.bibliographicCitation | D. López-Díaz, M. López Holgado, J.L. García-Fierro, M.M. Velázquez Evolution of the Raman spectrum with the chemical composition of graphene oxide J. Phys. Chem. C, 121 (37) (2017), pp. 20489-20497 | spa |
| dcterms.bibliographicCitation | D. Ma, X. Li, Y. Guo, Y. Zeng Study on IR properties of reduced graphene oxide IOP Conf. Ser. Earth Environ. Sci., 108 (2) (2018) | spa |
| dcterms.bibliographicCitation | Y. Pan, T. Wu, H. Bao, L. Li Green fabrication of chitosan films reinforced with parallel aligned graphene oxide Carbohydr. Polym., 83 (4) (2011), pp. 1908-1915 | spa |
| dcterms.bibliographicCitation | K.S.S.K. Muhamad, F. Mohamed, S. Radiman, A. Hamzah, S. Sarmani, K.K. Siong, M.S. Yasir, I.A. Rahman, N.R.A.M. Rosli Synthesis and characterization of exfoliated graphene oxide AIP Conf. Proc. (2016), p. 1784 | spa |
| dcterms.bibliographicCitation | D. Han, L. Yan, W. Chen, W. Li Preparation of chitosan/graphene oxide composite film with enhanced mechanical strength in the wet state Carbohydr. Polym., 83 (2) (2011), pp. 653-658 | spa |
| dcterms.bibliographicCitation | M.S. Muda, A. Kamari, S.A. Bakar, S.N.M. Yusoff, I. Fatimah, E. Phillip, S.M. Din Chitosan-graphene oxide nanocomposites as water-solubilising agents for rotenone pesticide J. Mol. Liq., 318 (2020), p. 114066 | spa |
| dcterms.bibliographicCitation | W.F. Khalil, G.S. El-Sayyad, W.M.A. El Rouby, M.A. Sadek, A.A. Farghali, A.I. El-Batal Graphene oxide-based nanocomposites (GO-Chitosan and GO-EDTA) for outstanding antimicrobial potential against some Candida species and pathogenic bacteria Int. J. Biol. Macromol., 164 (2020), pp. 1370-1383 | spa |
| dcterms.bibliographicCitation | C. Qin, H. Li, Q. Xiao, Y. Liu, J. Zhu, Y. Du Water-solubility of chitosan and its antimicrobial activity Carbohydr. Polym., 63 (3) (2006), pp. 367-374 | spa |
| dcterms.bibliographicCitation | G. Muñoz, C. Valencia, N. Valderruten, E. Ruiz-Durántez, F. Zuluaga Extraction of chitosan from Aspergillus Niger mycelium and synthesis of hydrogels for controlled release of betahistine React. Funct. Polym., 91–92 (June) (2015), pp. 1-10 | spa |
| dcterms.bibliographicCitation | E.S. Alvarenga Characterization and properties of chitosan Biotechnol. Biopolym. (2011), pp. 91-108 | spa |
| dcterms.bibliographicCitation | I. Younes, S. Hajji, V. Frachet, M. Rinaudo, K. Jellouli, M. Nasri Chitin extraction from shrimp shell using enzymatic treatment. Antitumor, antioxidant and antimicrobial activities of chitosan Int. J. Biol. Macromol., 69 (2014), pp. 489-498 | spa |
| dcterms.bibliographicCitation | A.B. Muley, S.A. Chaudhari, K.H. Mulchandani, R.S. Singhal Extraction and characterization of chitosan from prawn shell waste and its conjugation with cutinase for enhanced thermo-stability Int. J. Biol. Macromol., 111 (2018), pp. 1047-1050 | spa |
| dcterms.bibliographicCitation | P.G. Ren, D.X. Yan, X. Ji, T. Chen, Z.M. Li Temperature dependence of graphene oxide reduced by hydrazine hydrate Nanotechnology, 22 (5) (2011) | spa |
| dcterms.bibliographicCitation | P. de A. Sarmento, T. da R. Ataíde, A.P. de S. Pinto, J.X. de Araújo-Júnior, I.M.L. Lúcio, M.L. de A. Bastos Avaliação do extrato da zeyheria tuberculosa Na perspectiva de Um produto para cicatrização de Feridas Rev. Lat. Am. Enfermagem, 22 (1) (2014), pp. 165-172 | spa |
| dcterms.bibliographicCitation | M. Jannasch, T. Weigel, L. Engelhardt, J. Wiezoreck, S. Gaetzner, H. Walles, T. Schmitz, J. Hansmann In vitro chemotaxis and tissue remodeling assays quantitatively characterize foreign body reaction ALTEX, 34 (2) (2017), pp. 253-266 | spa |
| dcterms.bibliographicCitation | M. Tomida, K. Nakano, S. Matsuura, T. K Comparative examination of subcutaneous tissue reation to high molecular materials in medical use Eur. J. Med. Res. (2011), pp. 249-252 | spa |
| dcterms.bibliographicCitation | S. Al-Maawi, C. Mota, A. Kubesch, C. James Kirkpatrick, L. Moroni, S. Ghanaati Multiwell three-dimensional systems enable in vivo screening of immune reactions to biomaterials: a new strategy toward translational biomaterial research J. Mater. Sci. Mater. Med., 30 (6) (2019), pp. 1-6 | spa |
| dcterms.bibliographicCitation | J.M. Anderson, A. Rodriguez, D.T. Chang Foreign body reaction to biomaterials Semin. Immunol., 20 (2) (2008), pp. 86-100 | spa |
| dcterms.bibliographicCitation | D.S. Steinbrech, M.T. Longaker, B.J. Mehrara, P.B. Saadeh, G.S. Chin, R.P. Gerrets, D.C. Chau, N.M. Rowe, G.K. Gittes Fibroblast response to hypoxia: the relationship between angiogenesis and matrix regulation J. Surg. Res., 84 (2) (1999), pp. 127-133 | spa |
| dcterms.bibliographicCitation | P. Kumar, S. Kumar, E.P. Udupa, U. Kumar, P. Rao, T. Honnegowda Role of angiogenesis and angiogenic factors in acute and chronic wound healing Plast. Aesthetic Res., 2 (5) (2015), p. 243 | spa |
| dcterms.bibliographicCitation | S.M. Sari Kiliçaslan, Ş. Coşkun Cevher, E.G. Güleç Peker Ultrastructural changes in blood vessels in epidermal growth factor treated experimental cutaneous wound model Pathol. Res. Pract., 209 (11) (2013), pp. 710-715 | spa |
| dcterms.bibliographicCitation | M.R. Major, V.W. Wong, E.R. Nelson, M.T. Longaker, G.C. Gurtner The foreign body response: at the interface of surgery and bioengineering Plast. Reconstr. Surg., 135 (5) (2015), pp. 1489-1498 | spa |
| datacite.rights | http://purl.org/coar/access_right/c_abf2 | spa |
| oaire.resourcetype | http://purl.org/coar/resource_type/c_2df8fbb1 | spa |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | spa |
| dc.audience | Público general | spa |
| dc.identifier.doi | 10.1016/j.heliyon.2021.e07058. | |
| dc.identifier.instname | Universidad del Atlántico | spa |
| dc.identifier.reponame | Repositorio Universidad del Atlántico | spa |
| dc.rights.cc | Attribution-NonCommercial 4.0 International | * |
| dc.subject.keywords | Chitosan Graphene oxide Regenerative medicine Tissue engineering | spa |
| dc.type.driver | info:eu-repo/semantics/article | spa |
| dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | spa |
| dc.type.spa | Artículo | spa |
| dc.publisher.place | Barranquilla | spa |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | spa |
| dc.publisher.discipline | Química | spa |
| dc.publisher.sede | Sede Norte | spa |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
Excepto si se señala otra cosa, la licencia del ítem se describe como http://creativecommons.org/licenses/by-nc/4.0/
Tecnología DSpace implementada por 