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Design, characterization and quantum chemical computations of a novel series of pyrazoles derivatives with potential anti-proinflammatory response

dc.contributor.authorBurboa-Schettino, Pia
dc.contributor.otherBustos, Carlos
dc.contributor.otherMolins, Elies
dc.contributor.otherFigueroa, Xavier F
dc.contributor.otherLlanquinao, Jesus
dc.contributor.otherZarate, Ximena
dc.contributor.otherVallejos, Gabriel
dc.contributor.otherDiaz-Uribe, Carlos
dc.contributor.otherVallejo, William
dc.contributor.otherSchott, Eduardo
dc.date.accessioned2022-11-15T21:01:54Z
dc.date.available2022-11-15T21:01:54Z
dc.date.issued2020-06-24
dc.date.submitted2020-03-21
dc.identifier.urihttps://hdl.handle.net/20.500.12834/924
dc.description.abstractThe synthesis and characterization of the full family of 11 pyrazoles were performed by means of UV–Vis, FTIR, 1 H NMR, 13C NMR, two-dimensional NMR experiments and DFT simulations. As pyrazoles are known for showing diverse biological actions, they were also tested in the NCI-60 cancer cell line panel, showing moderate to good activity against different cell lines. Furthermore, the anti-proinflammatory activity test of a set of pyrazoles of the form (E)-4-((4-bro mophenyl)diazenyl)-3,5-dimethyl-1-R-phenyl-1H-pyrazole was performed, this is based on the study of the blockage of the increase in intracellular [Ca2+] observed in response to plateletactivating factor (PAF) treatment of four pyrazoles (i.e. 6, 8, 9 and 10), which successfully displayed [Ca2+] channel inhibition. Therefore, the obtained intracellular [Ca2+] signal results indicate that the pyrazole family characterized in this study, in particular compounds 6 and 10, are potent blockers of the PAF-initiated Ca2+ signaling that mediates the hyperpermeability typically observed during the development of inflammation.spa
dc.format.mimetypeapplication/pdfspa
dc.language.isoengspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourceArabian Journal of Chemistryspa
dc.titleDesign, characterization and quantum chemical computations of a novel series of pyrazoles derivatives with potential anti-proinflammatory responsespa
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datacite.rightshttp://purl.org/coar/access_right/c_abf2spa
oaire.resourcetypehttp://purl.org/coar/resource_type/c_6501spa
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85spa
dc.audiencePúblico generalspa
dc.identifier.doi10.1016/j.arabjc.2020.05.042
dc.identifier.instnameUniversidad del Atlánticospa
dc.identifier.reponameRepositorio Universidad del Atlánticospa
dc.rights.ccAttribution-NonCommercial 4.0 International*
dc.subject.keywordsAnti-proinflammatory; Platelet-activating factor; Pyrazoles;spa
dc.type.driverinfo:eu-repo/semantics/articlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículospa
dc.publisher.placeBarranquillaspa
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessspa
dc.publisher.disciplineQuímicaspa
dc.publisher.sedeSede Nortespa


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